The film begins with a prologue that showcases the origins of the mutant family that inhabits the desolate desert landscape. The prologue takes the audience back to the 1940s, where a family of mutants, led by Papa Jupiter (Randy J. Goodwin), is shown to be surviving in the harsh desert environment. The mutants are a result of a nuclear test that took place in the area, which caused them to mutate and become deformed.

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The Hills Have Eyes is a 2006 American horror film directed by Alexandre Aja and co-written by Aja and Grégory Levasseur. The movie is a remake of the 1977 film of the same name by Wes Craven. The film stars Sheryl Crow, Aya Cash, and Emile Hirsch. The movie follows a family's terrifying experience when they become stranded in the middle of the desert and are stalked by a family of cannibal mutants.

As night falls, the family is ambushed by the mutant family, led by Big Bob (Alan Bastion). The mutants, who are cannibals, begin to stalk and hunt the Carter family. The family fights for survival, and in the process, they uncover the dark secrets of the desert and the mutant family.