Trisha has collaborated with director Puri Jagannadh on several films, including "Pokiri" (2006) and "Baddest Telugu" (2006). The duo shares a close professional relationship, and Trisha has often spoken about her admiration for the director. Although there have been rumors about a possible romantic connection between the two, Trisha has clarified that their relationship is purely professional.

Trisha began her acting career in the late 1990s, making her debut in the Tamil film "Jodi" (1999). However, it was her breakthrough role in the Telugu film "Chitti Babu" (2001) that catapulted her to fame. Her performance earned her critical acclaim and recognition, marking the beginning of a successful career.

Trisha is currently single and focused on her acting career. She has been open about her struggles with depression and anxiety, using her platform to raise awareness about mental health. The actress continues to be a part of several film projects, including web series and films.

Trisha has been linked to several co-stars and industry personalities over the years. One of her most rumored relationships was with actor Siddique, with whom she starred in several films, including "Nuvvu Nenu" (2002) and "Lakshyam" (2007). However, the actress has always maintained that their relationship was platonic.